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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Eric Price | 0.136 | 2032 | |
| 2 | Salvador Selame# | 0.867 | 2049 | |
| 3 | Tyrone Walls | 0.960 | 2038 | |
| 4 | Francisco Méndez | 1.155 | 2033 | |
| 5 | Artie Bryant | 1.244 | 2045 | |
| 6 | Jaime Hernández | 1.293 | 2052 | |
| 7 | Román Luna | 1.299 | 2034 | |
| 8 | Valentín Morín | 1.492 | 2051 | |
| 9 | Luis Martínez* | 1.500 | 2032 | |
| 10 | Jeff Simon# | 1.526 | 2055 | |
| 11 | Amine Guilbert | 1.550 | 2059 | |
| 12 | Luis Cadena | 1.606 | 2029 | |
| 13 | Chris Booth# | 1.625 | 2052 | |
| 14 | Mike McIntosh | 1.650 | 2044 | |
| 15 | Joaquín Gutiérrez | 1.688 | 2040 | |
| 16 | Cletus Ayotte | 1.695 | 2037 | |
| 17 | Glenn Keeler | 1.728 | 2035 | |
| 18 | Ben Lozano | 1.729 | 2030 | |
| 19 | Fernando Salazar# | 1.742 | 2064 | |
| 19 | Bernardo Mota | 1.742 | 2053 | |
| 21 | Jorge Rijo# | 1.764 | 2057 | |
| 22 | Jason Livingston# | 1.766 | 2059 | |
| 23 | Eric Price | 1.774 | 2031 | |
| 24 | Marat Trafimov# | 1.792 | 2059 | |
| 25 | Ricardo Beltrán | 1.817 | 2040 | |
| 26 | Edmond Zimmerman | 1.819 | 2053 | |
| 27 | António Medina# | 1.831 | 2056 | |
| 28 | Ricky Hyatt | 1.838 | 2048 | |
| 29 | Vicente Paz | 1.846 | 2038 | |
| 30 | Alberto Flores | 1.955 | 2039 | |
| 31 | Erik Gentry# | 1.968 | 2064 | |
| 32 | Manny Acosta | 1.992 | 2032 | |
| 33 | Júlio Balderas# | 1.995 | 2059 | |
| 34 | John Cherry | 2.007 | 2033 | |
| 34 | Jaime Vásquez | 2.007 | 2033 | |
| 36 | Mike Brown | 2.017 | 2033 | |
| 37 | Eric Short | 2.040 | 2037 | |
| 38 | Francisco Solís | 2.069 | 2046 | |
| 39 | Flynn Hogan | 2.095 | 2038 | |
| 40 | Kenny Sánchez# | 2.125 | 2054 | |
| 41 | Jesús Arredondo | 2.179 | 2039 | |
| 42 | Eddie Ramales | 2.192 | 2033 | |
| 43 | Augusto González | 2.204 | 2031 | |
| 44 | Timothy Flannery# | 2.215 | 2064 | |
| 45 | Colter Harrison# | 2.238 | 2055 | |
| 46 | Bill Palmer | 2.250 | 2041 | |
| 47 | Júlio Reyes# | 2.278 | 2063 | |
| 48 | Joseph Bonney | 2.282 | 2033 | |
| 49 | Anastasio Serrano | 2.292 | 2043 | |
| 50 | Alberto Flores | 2.303 | 2037 | |
| 51 | Chang-hyun O | 2.311 | 2039 | |
| 52 | Hamilton Tucker# | 2.328 | 2064 | |
| 53 | Martin Haase# | 2.330 | 2059 | |
| 54 | Santiago Castro | 2.348 | 2039 | |
| 55 | Ernest Martin# | 2.353 | 2060 | |
| 56 | Tomás González | 2.354 | 2043 | |
| 56 | Todd Osborn# | 2.354 | 2058 | |
| 58 | Craig Leach | 2.371 | 2036 | |
| 59 | Tomás Torres | 2.379 | 2046 | |
| 60 | Kevin Lane | 2.386 | 2042 | |
| 61 | José Saldaña# | 2.403 | 2056 | |
| 62 | Philip Bruce | 2.442 | 2045 | |
| 63 | Félix Rosado | 2.455 | 2039 | |
| 63 | Al Brown | 2.455 | 2030 | |
| 63 | Roberto Díaz | 2.455 | 2045 | |
| 66 | Bob Owen# | 2.465 | 2063 | |
| 67 | Juan Vásquez# | 2.477 | 2058 | |
| 68 | Mark Pearson | 2.484 | 2036 | |
| 68 | Nick Sheppard# | 2.484 | 2051 | |
| 70 | Stanton Rodgers | 2.492 | 2032 | |
| 70 | Dave Beaumond | 2.492 | 2032 | |
| 72 | Heng-zong Koh | 2.502 | 2044 | |
| 73 | Jon Hill | 2.509 | 2045 | |
| 74 | Eric Mills | 2.531 | 2040 | |
| 75 | Mark Lewis# | 2.535 | 2058 | |
| 76 | Don Wilson# | 2.541 | 2064 | |
| 77 | Tim Robinson | 2.561 | 2037 | |
| 78 | Lancelot Mueller | 2.565 | 2035 | |
| 79 | Ryan Rouhan | 2.571 | 2044 | |
| 80 | Jorge Ramírez# | 2.591 | 2059 | |
| 81 | Will Caine | 2.609 | 2044 | |
| 82 | Bartolo Álvarez | 2.621 | 2038 | |
| 83 | Lonnie Reynolds# | 2.634 | 2059 | |
| 84 | Miguel Encarnación | 2.644 | 2033 | |
| 84 | Lee Mitchell | 2.644 | 2041 | |
| 86 | Doug O'Slattery | 2.647 | 2039 | |
| 87 | Matt Cooper | 2.650 | 2038 | |
| 88 | Tomás Flores# | 2.665 | 2059 | |
| 89 | Gustavo Ramos# | 2.673 | 2061 | |
| 90 | Andrew Lucas | 2.676 | 2039 | |
| 91 | Lonnie Reynolds# | 2.679 | 2060 | |
| 92 | Joe Lowe# | 2.686 | 2059 | |
| 93 | Tucker Hayes# | 2.687 | 2057 | |
| 94 | Ron Davis | 2.690 | 2039 | |
| 95 | Ángelo López | 2.700 | 2045 | |
| 95 | Douglas Reed | 2.700 | 2048 | |
| 95 | Michael Lewis | 2.700 | 2034 | |
| 95 | Carlos Hernández | 2.700 | 2035 | |
| 99 | Joey Fox# | 2.721 | 2054 | |
| 100 | Miguel Angel Chávez# | 2.724 | 2054 |
