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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Fa-hsien Huang | 0.529 | 2029-2047 | |
| 2 | Edgardo Leal* | 1.151 | 2040-2057 | |
| 3 | Paul Bailey | 1.174 | 2034-2048 | |
| 4 | Leonard James | 1.434 | 2033-2043 | |
| 5 | Joe Romero | 1.446 | 2021-2031 | |
| 6 | Júlio Rodríguez* | 1.512 | 2036-2055 | |
| 7 | Carl Green | 1.549 | 2030-2038 | |
| 8 | Chin Kang | 1.688 | 2029-2045 | |
| 9 | Bob Taylor | 1.717 | 2029-2040 | |
| 10 | Carlos Delgado# | 1.780 | 2062-2070 | |
| 11 | Fernando Franco# | 1.783 | 2066-2070 | |
| 12 | Francisco Fernández | 1.800 | 2034-2046 | |
| 13 | Marcos López | 1.852 | 2036-2047 | |
| 14 | Jon Gilmore# | 1.856 | 2064-2070 | |
| 15 | William Echeverria* | 1.912 | 2015-2029 | |
| 16 | Charles Rushing | 1.940 | 2022-2035 | |
| 17 | Munenori Ogawa | 2.000 | 2041-2056 | |
| 18 | Rafael Barilla | 2.015 | 2049-2063 | |
| 19 | Juan Gómez* | 2.032 | 2039-2055 | |
| 20 | Bill Wood | 2.077 | 2032-2036 | |
| 21 | Kenneth Mazzariello | 2.133 | 2016-2030 | |
| 22 | Avery Craig# | 2.160 | 2058-2070 | |
| 23 | Felipe Delgado# | 2.162 | 2063-2070 | |
| 24 | José Cordero | 2.167 | 2028-2040 | |
| 25 | Jerry Young Jr.# | 2.189 | 2061-2070 | |
| 26 | Juan Sánchez | 2.235 | 2038-2054 | |
| 27 | Shojiro Ageda# | 2.269 | 2061-2070 | |
| 28 | Bartolo Salas* | 2.282 | 2020-2035 | |
| 29 | Loren Berrian* | 2.285 | 2021-2040 | |
| 30 | Juan Tirado* | 2.356 | 2030-2046 | |
| 31 | Edgar Dailey* | 2.362 | 2043-2057 | |
| 32 | Ron Collins# | 2.364 | 2060-2070 | |
| 33 | Steve Sanders | 2.376 | 2039-2047 | |
| 34 | Lee Costa# | 2.391 | 2059-2070 | |
| 35 | Stephen Dundee# | 2.393 | 2060-2070 | |
| 36 | Mario Segura | 2.414 | 2051-2066 | |
| 37 | Samuel Corley* | 2.444 | 2042-2057 | |
| 38 | James Dunham | 2.473 | 2055-2067 | |
| 39 | Manny Negrón | 2.500 | 2042-2058 | |
| 39 | Pedro Rivero | 2.500 | 2029-2043 | |
| 41 | Gordon Ziersch# | 2.514 | 2065-2070 | |
| 42 | Ray Hunnicutt | 2.538 | 2056-2066 | |
| 43 | Tony Blanco | 2.547 | 2033-2049 | |
| 43 | Luis Pérez | 2.547 | 2049-2057 | |
| 43 | Leonard Johnston# | 2.547 | 2062-2070 | |
| 46 | Ted Duke# | 2.560 | 2061-2070 | |
| 47 | Johnny Lee | 2.562 | 2045-2057 | |
| 48 | Vidal Rodríguez | 2.581 | 2028-2041 | |
| 49 | Russ Lee* | 2.609 | 2032-2053 | |
| 50 | Jesús Gamboa | 2.613 | 2027-2040 | |
| 50 | Félix Rosado | 2.613 | 2042-2054 | |
| 52 | José García | 2.647 | 2031-2046 | |
| 53 | Oscar Cook | 2.652 | 2042-2056 | |
| 54 | Jeffrey Williams | 2.653 | 2048-2065 | |
| 55 | Mark Mitchell | 2.659 | 2044-2054 | |
| 56 | Alexander Magee# | 2.662 | 2065-2070 | |
| 57 | Rory Faulkner | 2.676 | 2038-2052 | |
| 58 | James Landeros | 2.679 | 2027-2037 | |
| 59 | Juan Santana* | 2.680 | 2038-2054 | |
| 60 | Hoyt Murphy# | 2.681 | 2058-2070 | |
| 61 | Víctor Castro | 2.711 | 2039-2056 | |
| 62 | Oscar Pineda | 2.721 | 2034-2051 | |
| 63 | Kenneth Benton | 2.732 | 2024-2038 | |
| 64 | Esteban Saucedo | 2.736 | 2027-2045 | |
| 65 | George Hernández* | 2.737 | 2044-2059 | |
| 66 | Luis Franco | 2.781 | 2038-2055 | |
| 67 | Chris Topper* | 2.788 | 2015-2030 | |
| 68 | Curt Brown# | 2.827 | 2063-2070 | |
| 69 | Mark Beatty | 2.856 | 2045-2057 | |
| 70 | Fernando Hernández# | 2.903 | 2057-2070 | |
| 71 | Tim Williams | 2.908 | 2043-2056 | |
| 72 | Tyrone Walls | 2.927 | 2040-2054 | |
| 73 | Maurice Corbett | 2.935 | 2040-2054 | |
| 74 | Ricardo Soriano | 2.939 | 2051-2063 | |
| 75 | Martin Johnson | 2.945 | 2041-2055 | |
| 76 | Pedro Solíz# | 2.950 | 2057-2068 | |
| 77 | Allen Colorado | 2.953 | 2024-2038 | |
| 78 | Kelvin Miller* | 2.958 | 2034-2058 | |
| 79 | Michael Rushton | 2.970 | 2023-2038 | |
| 80 | Rick Ball | 2.971 | 2051-2070 | |
| 81 | Roy Aronson | 2.975 | 2028-2040 | |
| 82 | José Ramírez | 2.976 | 2055-2069 | |
| 83 | Mike Horne | 2.983 | 2052-2061 | |
| 84 | Nate Ward* | 2.990 | 2046-2062 | |
| 85 | José Hernández | 3.000 | 2044-2058 | |
| 85 | Edward Rascoe# | 3.000 | 2063-2070 | |
| 87 | Vicente Heredia | 3.019 | 2037-2045 | |
| 88 | Tom Bolden | 3.024 | 2030-2043 | |
| 89 | Víctor Lugo | 3.031 | 2041-2054 | |
| 89 | Víctor Márquez | 3.031 | 2038-2053 | |
| 91 | Jacob Harris | 3.047 | 2038-2053 | |
| 92 | David Clark | 3.086 | 2043-2055 | |
| 92 | Eugene Sampson | 3.086 | 2028-2046 | |
| 94 | Don Gibbs# | 3.098 | 2061-2070 | |
| 94 | William Jones | 3.098 | 2029-2043 | |
| 96 | Keith Campbell | 3.101 | 2042-2051 | |
| 96 | Jasper James | 3.101 | 2043-2058 | |
| 98 | Carlos Ojeda | 3.102 | 2029-2043 | |
| 99 | Chris Jouan# | 3.106 | 2065-2070 | |
| 100 | David Warren* | 3.115 | 2020-2035 |
